Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGMN | Q99538 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 13/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CTSB | P07858 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6499616 | 0.84 | MAPT (0.81) | MAPTALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL6529147 | 0.82 | MAPT (0.68) | LGMNMAPTALDH1A1LMNATDP1 | |
| SCHEMBL38658829 | 0.82 | MAPT (0.75) | LGMNMAPTALDH1A1TDP1TP53 | |
| SCHEMBL20522603 | 0.81 | MAPT (0.63) | LGMNMAPTALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL2062463 | 0.81 | MAPT (0.64) | LGMNMAPTALDH1A1TDP1TP53 | |
| SCHEMBL3537665 | 0.81 | MAPT (0.73) | MAPTALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL9692032 | 0.81 | MAPT (0.72) | LGMNMAPTALDH1A1TP53HTT | |
| SCHEMBL3435047 | 0.80 | MAPT (0.69) | LGMNMAPTALDH1A1LMNAHPGD | |
| SCHEMBL27774 | 0.79 | MAPT (1.00) | LGMNMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL400816 | 0.79 | MAPT (0.79) | LGMNMAPTALDH1A1TP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |