Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | CTSB | P07858 | 1/20 | 0.60 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | LGMN | Q99538 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | S100A4 | P26447 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3435998 | 0.91 | MAPT (0.74) | MAPTL3MBTL1HTTTP53ALDH1A1 | |
| SCHEMBL8312209 | 0.87 | MAPT (0.72) | MAPTL3MBTL1HTTTP53ALDH1A1 | |
| SCHEMBL20522603 | 0.86 | MAPT (0.63) | MAPTL3MBTL1HTTTP53ALDH1A1 | |
| SCHEMBL13648194 | 0.84 | MAPT (0.64) | MAPTL3MBTL1HTTTP53ALDH1A1 | |
| SCHEMBL3435047 | 0.84 | MAPT (0.69) | MAPTHTTTP53ALDH1A1CTSB | |
| SCHEMBL17542826 | 0.82 | LGMN (0.59) | MAPTHTTTP53ALDH1A1LGMN | |
| SCHEMBL2041681 | 0.82 | MAPT (0.79) | MAPTL3MBTL1ALDH1A1POLBLMNA | |
| SCHEMBL6507535 | 0.82 | LGMN (0.71) | MAPTHTTTP53ALDH1A1CTSB | |
| SCHEMBL17305299 | 0.81 | LGMN (0.56) | MAPTHTTALDH1A1POLBLGMN | |
| SCHEMBL3436573 | 0.81 | MEN1 (0.61) | MAPTHTTTP53ALDH1A1LGMN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |