Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K8 | P41279 | 3/20 | 0.53 |
| ▸ | WNT1 | P04628 | 9/20 | 0.51 |
| ▸ | CLK2 | P49760 | 8/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.47 |
| ▸ | CLK3 | P49761 | 6/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6511342 | 0.93 | CDK1 (0.46) | MAP3K8WNT1CLK2DYRK1ACLK3 | |
| SCHEMBL6507878 | 0.92 | MAP3K8 (0.50) | MAP3K8WNT1CLK2DYRK1ACLK3 | |
| SCHEMBL6504553 | 0.84 | MAP3K8 (0.76) | MAP3K8CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL6501756 | 0.76 | MAP3K8 (0.68) | MAP3K8CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL6501818 | 0.75 | MAP3K8 (0.74) | MAP3K8CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL6502024 | 0.74 | MAP3K8 (0.55) | MAP3K8WNT1CDK1CCNB1CCNA2 | |
| SCHEMBL6501453 | 0.73 | MAP3K8 (0.64) | MAP3K8CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL15306641 | 0.72 | CLK2 (0.65) | WNT1CLK2DYRK1ACLK3CLK1 | |
| SCHEMBL6504609 | 0.72 | MAP3K8 (0.71) | MAP3K8WNT1CLK2DYRK1ACLK3 | |
| SCHEMBL15306640 | 0.72 | CLK2 (0.68) | WNT1CLK2DYRK1ACLK3CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050090529-A1 | 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | PFIZER INC | 2005-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050090529-A1 | 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | CDK3, CDK4, CDK9 | MAP3K8 143/4885WNT1 640/4885CLK2 492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.