Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 10/20 | 0.72 |
| ▸ | AURKA | O14965 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 1/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MYLK | Q15746 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | RORA | P35398 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | RORB | Q92753 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6507426 | 0.93 | CHEK1 (0.71) | CHEK1AURKAKDRAURKBKCNH2 | |
| SCHEMBL4004208 | 0.87 | CHEK1 (0.71) | CHEK1AURKAKDRAURKBKCNH2 | |
| SCHEMBL6508702 | 0.86 | CHEK1 (0.56) | CHEK1AURKAKDRAURKBKCNH2 | |
| SCHEMBL6510579 | 0.86 | CHEK1 (0.80) | CHEK1AURKAKDRAURKBKCNH2 | |
| SCHEMBL6522349 | 0.86 | AURKA (0.62) | CHEK1AURKAKDRAURKBKCNH2 | |
| SCHEMBL6517711 | 0.85 | CHEK1 (0.55) | CHEK1AURKAKDRAURKBKCNH2 | |
| SCHEMBL6512695 | 0.85 | CHEK1 (0.78) | CHEK1AURKAKDRAURKBKCNH2 | |
| SCHEMBL6508848 | 0.84 | AURKA (0.54) | CHEK1AURKAKDRAURKBKCNH2 | |
| SCHEMBL6514092 | 0.84 | CHEK1 (0.67) | CHEK1AURKAKDRAURKBKCNH2 | |
| SCHEMBL6517619 | 0.84 | CHEK1 (0.77) | CHEK1AURKAKDRAURKBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-11-03 | — | — | US | disclosed |
| WO-2005028474-A2 | PYRAZOLOQUINOLINE DERIVATIVES AS CHK-1 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | CHKA, CHKB, CHEK1 | CHEK1 3/4885AURKA 78/4885KDR 1094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.