Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 15/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.65 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6507581 | 0.87 | CHEK1 (0.72) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL6510579 | 0.85 | CHEK1 (0.80) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL6512695 | 0.84 | CHEK1 (0.78) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL6518285 | 0.83 | CHEK1 (0.67) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL6508884 | 0.83 | CHEK1 (0.77) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL6515391 | 0.83 | CHEK1 (0.77) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL6517703 | 0.83 | CHEK1 (1.00) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL6517619 | 0.83 | CHEK1 (0.77) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL6514092 | 0.83 | CHEK1 (0.67) | CHEK1KCNH2AURKAKDRAURKB | |
| SCHEMBL6518189 | 0.83 | CHEK1 (0.77) | CHEK1KCNH2AURKAKDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7485649-B2 | Inhibitors of checkpoint kinases | MERCK & CO., INC. (US) | 2009-02-03 | — | — | US | claimed |
| US-20080214594-A1 | Inhibitors Of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2008-09-04 | — | — | US | claimed |
| US-7485649-B2 | Inhibitors of checkpoint kinases | MERCK & CO., INC. (US) | 2009-02-03 | — | — | US | disclosed |
| US-7485649-B2 | Inhibitors of checkpoint kinases | MERCK & CO., INC. (US) | 2009-02-03 | — | — | US | disclosed |
| US-7485649-B2 | Inhibitors of checkpoint kinases | MERCK & CO., INC. (US) | 2009-02-03 | — | — | US | disclosed |
| US-20080214594-A1 | Inhibitors Of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2008-09-04 | — | — | US | disclosed |
| US-20080214594-A1 | Inhibitors Of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2008-09-04 | — | — | US | disclosed |
| US-20080214594-A1 | Inhibitors Of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214594-A1 | Inhibitors Of Checkpoint Kinases | CHEK1, CHEK2, BUB1B | CHEK1 1/4885KCNH2 2921/4885AURKA 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.