Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | WNT3A | P56704 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 8/20 | 0.45 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17872892 | 0.85 | EGFR (0.69) | EGFRCNR1WNT3APIK3C3GSK3B | |
| SCHEMBL17631827 | 0.83 | MKNK1 (0.53) | EGFRCNR1WNT3APIK3C3MAPK8 | |
| SCHEMBL17010231 | 0.82 | NR3C2 (0.44) | EGFRPIK3C3 | |
| SCHEMBL6507708 | 0.81 | PIP5K1C (0.63) | EGFRCNR1WNT3APIP5K1CPIK3CA | |
| SCHEMBL6502882 | 0.80 | IRAK4 (0.49) | EGFRMAP4K4PIK3C3GSK3B | |
| SCHEMBL1026072 | 0.79 | FFAR1 (0.47) | PIK3CA | |
| SCHEMBL1026728 | 0.78 | NR3C2 (0.64) | MAOA | |
| SCHEMBL6508127 | 0.77 | CGAS (0.44) | EGFRPIK3C3GSK3BMAPK8MAPK10 | |
| SCHEMBL6508122 | 0.77 | CGAS (0.44) | EGFRPIK3C3GSK3BMAPK8MAPK10 | |
| SCHEMBL17872874 | 0.74 | KDM4E (0.51) | EGFRCNR1WNT3AGSK3BMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003123-A1 | NOVEL PYRIDINE DERIVATIVES AS JNK SPECIFIC INHIBITORS | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |