Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP5K1C | O60331 | 9/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.63 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
| ▸ | PIP5K1B | O14986 | 2/20 | 0.53 |
| ▸ | PIP5K1A | Q99755 | 2/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.53 |
| ▸ | PI4KA | P42356 | 1/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.53 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.53 |
| ▸ | WNT3A | P56704 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17872892 | 0.88 | EGFR (0.69) | PIP5K1CPIK3CAMAPK8MAPK10MAPK14 | |
| SCHEMBL6500941 | 0.83 | PIP5K1C (0.53) | PIP5K1CPIK3CAACVRL1MAPK8MAPK10 | |
| SCHEMBL6500932 | 0.83 | PIP5K1C (0.53) | PIP5K1CPIK3CAACVRL1MAPK8MAPK10 | |
| SCHEMBL6501406 | 0.82 | PIP5K1C (0.54) | PIP5K1CPIK3CAACVRL1MAPK8MAPK10 | |
| SCHEMBL6507679 | 0.81 | EGFR (0.54) | PIP5K1CPIK3CAMAPK8MAPK10EGFR | |
| SCHEMBL1518723 | 0.79 | CNR1 (0.69) | PIP5K1CPIK3CAACVRL1MAPK8MAPK10 | |
| SCHEMBL1518824 | 0.79 | PIP5K1C (0.68) | PIP5K1CPIK3CAACVRL1MAPK8MAPK10 | |
| SCHEMBL6504987 | 0.78 | PIP5K1C (1.00) | PIP5K1CPIK3CAACVRL1MAPK8MAPK10 | |
| SCHEMBL6505284 | 0.78 | MAPK10 (0.88) | PIP5K1CPIK3CAACVRL1MAPK8MAPK10 | |
| SCHEMBL13151491 | 0.77 | MAPK10 (0.62) | PIP5K1CPIK3CAMAPK8MAPK10MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003123-A1 | NOVEL PYRIDINE DERIVATIVES AS JNK SPECIFIC INHIBITORS | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |