Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 12/20 | 0.63 |
| ▸ | TP53 | P04637 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6511759 | 0.95 | KDM4E (0.73) | KMT2AKDM4EHSD17B10PKMMAPT | |
| SCHEMBL6509292 | 0.87 | KDM4E (0.81) | KMT2AKDM4EHSD17B10PKMMAPT | |
| SCHEMBL6509340 | 0.85 | KDM4E (0.70) | KMT2AKDM4EHSD17B10PKMMAPT | |
| SCHEMBL5532732 | 0.83 | KDM4E (0.90) | KMT2AKDM4EHSD17B10PKMMAPT | |
| SCHEMBL5910282 | 0.81 | KMT2A (1.00) | KMT2AKDM4EHSD17B10PKMMAPT | |
| SCHEMBL5529827 | 0.79 | KDM4E (1.00) | KMT2AKDM4EHSD17B10PKMMAPT | |
| SCHEMBL16299047 | 0.78 | KDM4E (0.67) | KMT2AKDM4EHSD17B10PKMMAPT | |
| SCHEMBL6511778 | 0.78 | KDM4E (0.74) | KMT2AKDM4EHSD17B10PKMMAPT | |
| SCHEMBL6513981 | 0.77 | KDM4E (0.70) | KMT2AKDM4EHSD17B10PKMMAPT | |
| SCHEMBL6510716 | 0.77 | KDM4E (0.70) | KMT2AKDM4EHSD17B10PKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005087742-A1 | METABOLIC KINASE MODULATORS AND METHODS OF USE AS PESTICIDES | EXELIXIS, INC. (US) | 2005-09-22 | — | — | WO | claimed |
| WO-2005087742-A1 | METABOLIC KINASE MODULATORS AND METHODS OF USE AS PESTICIDES | EXELIXIS, INC. (US) | 2005-09-22 | — | — | WO | disclosed |