Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP5K1C | O60331 | 17/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.52 |
| ▸ | PIP5K1B | O14986 | 3/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.52 |
| ▸ | PI4KA | P42356 | 3/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.52 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.52 |
| ▸ | PIP5K1A | Q99755 | 3/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6501406 | 0.87 | PIP5K1C (0.54) | PIP5K1CPIK3CAPIK3CDPIP5K1BPDGFRB | |
| SCHEMBL5548970 | 0.81 | ATR (0.48) | — | |
| SCHEMBL5251219 | 0.80 | EGFR (0.57) | MAPK8MAPK10 | |
| SCHEMBL6509374 | 0.80 | PIP5K1C (0.80) | PIP5K1CPIK3CAPIK3CDPIP5K1BPDGFRB | |
| SCHEMBL6505419 | 0.78 | PIP5K1C (0.81) | PIP5K1CPIK3CAPIK3CDPIP5K1BPDGFRB | |
| SCHEMBL14359967 | 0.77 | ATR (0.53) | — | |
| SCHEMBL29640073 | 0.77 | ATR (0.53) | — | |
| SCHEMBL24010535 | 0.76 | BRAF (0.57) | — | |
| SCHEMBL1518666 | 0.75 | MAPK10 (0.70) | PIP5K1CPIK3CAPIP5K1BPIP5K1AMAPK8 | |
| SCHEMBL5544966 | 0.75 | CYP17A1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003123-A1 | NOVEL PYRIDINE DERIVATIVES AS JNK SPECIFIC INHIBITORS | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |
| WO-2005003140-A1 | 4-OXO-4,7-DIHYDROTHIENO[2,3-B]PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-01-13 | — | — | WO | disclosed |