Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | F2R | P25116 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649209 | 0.96 | C5AR1 (0.64) | C5AR1SMN1; SMN2LMNAL3MBTL1HSP90AA1 | |
| SCHEMBL5137882 | 0.91 | C5AR1 (0.71) | C5AR1SMN1; SMN2LMNAL3MBTL1HSP90AA1 | |
| SCHEMBL5137483 | 0.88 | C5AR1 (0.67) | C5AR1SMN1; SMN2LMNAL3MBTL1TSHR | |
| SCHEMBL649868 | 0.87 | C5AR1 (0.66) | C5AR1SMN1; SMN2LMNAL3MBTL1TSHR | |
| SCHEMBL651051 | 0.87 | C5AR1 (0.71) | C5AR1SMN1; SMN2LMNAL3MBTL1HSP90AA1 | |
| SCHEMBL648830 | 0.86 | C5AR1 (0.64) | C5AR1SMN1; SMN2LMNAL3MBTL1TSHR | |
| SCHEMBL4767016 | 0.86 | C5AR1 (0.75) | C5AR1SMN1; SMN2LMNAL3MBTL1HSP90AA1 | |
| SCHEMBL5136055 | 0.86 | C5AR1 (0.65) | C5AR1SMN1; SMN2LMNAL3MBTL1HSP90AA1 | |
| SCHEMBL5136318 | 0.86 | C5AR1 (0.65) | C5AR1SMN1; SMN2LMNAL3MBTL1HSP90AA1 | |
| SCHEMBL5135265 | 0.86 | C5AR1 (0.65) | C5AR1SMN1; SMN2LMNAL3MBTL1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786167-B2 | Ester derivatives; in vivo saponification by endogenous enzymes; dosage efficiency | IDEXX LABORATORIES, INC. (US) | 2010-08-31 | — | — | US | claimed |
| EP-2181706-A2 | Florfenicol esters for treating bacterial infections | IDEXX LABORATORIES, INC. (US) | 2010-05-05 | — | — | EP | claimed |
| US-20080306152-A1 | COMPOSITIONS CONTAINING PRODRUGS OF FLORFENICOL AND METHODS OF USE | IDEXX LBORATORIES, INC. (US) | 2008-12-11 | — | — | US | claimed |
| US-20080090912-A1 | Compositions containing prodrugs of florfenicol and methods of use | MURTHY YERRAMILLI V | 2008-04-17 | — | — | US | claimed |
| EP-1651202-A4 | COMPOSITIONS CONTAINING PRODRUGS OF FLORFENICOL AND METHODS OF USE | IDEXX LAB INC (US) | 2006-08-02 | — | — | EP | claimed |
| EP-1651202-A1 | COMPOSITIONS CONTAINING PRODRUGS OF FLORFENICOL AND METHODS OF USE | IDEXX LABORATORIES, INC. (US) | 2006-05-03 | — | — | EP | claimed |
| WO-2005009429-A1 | COMPOSITIONS CONTAINING PRODRUGS OF FLORFENICOL AND METHODS OF USE | IDEXX LABORATORIES, INC. (US) | 2005-02-03 | — | — | WO | claimed |
| US-20050014828-A1 | Compositions containing prodrugs of florfenicol and methods of use | IDEXX LABORATORIES, INC. | 2005-01-20 | — | — | US | claimed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119667-B2 | Carbonates of fenicol antibiotics | SCHERING-PLOUGH ANIMAL HEALTH CORPORATION (US) | 2012-02-21 | — | — | US | disclosed |
| EP-1966129-B1 | CARBONATES OF FENICOL ANTIBIOTICS | SCHERING PLOUGH LTD (CH) | 2011-08-17 | — | — | EP | disclosed |
| EP-2181706-A3 | Florfenicol esters for treating bacterial infections | IDEXX LABORATORIES, INC. (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2005009429-A1 | COMPOSITIONS CONTAINING PRODRUGS OF FLORFENICOL AND METHODS OF USE | IDEXX LABORATORIES, INC. (US) | 2005-02-03 | — | — | WO | disclosed |
| WO-2005009429-A1 | COMPOSITIONS CONTAINING PRODRUGS OF FLORFENICOL AND METHODS OF USE | IDEXX LABORATORIES, INC. (US) | 2005-02-03 | — | — | WO | disclosed |
| US-20050014828-A1 | Compositions containing prodrugs of florfenicol and methods of use | IDEXX LABORATORIES, INC. | 2005-01-20 | — | — | US | disclosed |
| US-20050014828-A1 | Compositions containing prodrugs of florfenicol and methods of use | IDEXX LABORATORIES, INC. | 2005-01-20 | — | — | US | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306152-A1 | COMPOSITIONS CONTAINING PRODRUGS OF FLORFENICOL AND METHODS OF USE | FAP, CYP3A5, CYP4F3 | C5AR1 1670/4885SMN1; SMN2 3536/4885LMNA 2883/4885 |
| US-20050014828-A1 | Compositions containing prodrugs of florfenicol and methods of use | FAP, CYP3A5, CYP4F3 | C5AR1 1670/4885SMN1; SMN2 3536/4885LMNA 2883/4885 |
| US-20080090912-A1 | Compositions containing prodrugs of florfenicol and methods of use | FAP, CYP3A5, CYP4F3 | C5AR1 1670/4885SMN1; SMN2 3536/4885LMNA 2883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.