Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 2/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.52 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.52 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5380305 | 0.89 | NTRK1 (0.58) | MEN1KMT2ARXFP1KCNK3KCNK9 | |
| SCHEMBL6322350 | 0.85 | LRRK2 (0.56) | MEN1KMT2AJAK2JAK1LRRK2 | |
| SCHEMBL6322335 | 0.83 | KDM4E (0.55) | MEN1KMT2AMAPTJAK2JAK1 | |
| SCHEMBL5382135 | 0.81 | LRRK2 (0.58) | LRRK2 | |
| SCHEMBL5372770 | 0.80 | JAK2 (0.66) | KCNK3KCNK9JAK2JAK1LRRK2 | |
| SCHEMBL4428095 | 0.79 | MEN1 (0.77) | MEN1KMT2ARXFP1KCNK3KCNK9 | |
| SCHEMBL5377833 | 0.79 | LRRK2 (0.47) | JAK2JAK1LRRK2NTRK1 | |
| SCHEMBL5381989 | 0.78 | AURKA (0.60) | KCNK3KCNK9JAK2JAK1LRRK2 | |
| SCHEMBL5372220 | 0.76 | MAP2K4 (0.65) | KMT2AMAPTJAK2JAK1LRRK2 | |
| SCHEMBL8251896 | 0.76 | CSNK1D (0.56) | MEN1KMT2AJAK2JAK1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009876-A1 | Indazole compounds, compositions thereof and methods of treatment therewith | SIGNAL PHARMACEUTICALS, LLC | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009876-A1 | Indazole compounds, compositions thereof and methods of treatment therewith | GPR119, JAK3, IGF1R | TTK 714/4885MAPK8 91/4885MEN1 4592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.