Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K8 | P41279 | 5/20 | 0.59 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CCND3 | P30281 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | CLK3 | P49761 | 5/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.45 |
| ▸ | CLK2 | P49760 | 4/20 | 0.45 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.45 |
| ▸ | WNT1 | P04628 | 4/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6503184 | 0.81 | CLK3 (0.49) | MAP3K8PRMT5WDR77CLK3DYRK1A | |
| SCHEMBL6500902 | 0.76 | MAP3K8 (0.73) | MAP3K8CDK4CCNA2CCND1CDK2 | |
| SCHEMBL6508329 | 0.76 | MAP3K8 (0.82) | MAP3K8CCNA2CDK2 | |
| SCHEMBL6508126 | 0.75 | MAP3K8 (0.73) | MAP3K8JAK2JAK1TYK2JAK3 | |
| SCHEMBL6508070 | 0.75 | MAP3K8 (1.00) | MAP3K8CCNA2CDK2 | |
| SCHEMBL6505118 | 0.74 | MAP3K8 (0.78) | MAP3K8CCNA2CDK2 | |
| SCHEMBL6509574 | 0.74 | MAP3K8 (0.81) | MAP3K8CCNA2CDK2 | |
| SCHEMBL7167622 | 0.73 | MAP3K8 (0.66) | MAP3K8CDK4CCNA2CCND1CDK2 | |
| SCHEMBL951209 | 0.70 | DYRK1A (0.54) | PRMT5WDR77CDK2CLK3DYRK1A | |
| SCHEMBL5377574 | 0.70 | CSNK1D (0.46) | MAP3K8CDK4CCNA2CCND1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050090529-A1 | 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | PFIZER INC | 2005-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050090529-A1 | 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | CDK3, CDK4, CDK9 | MAP3K8 143/4885PRMT5 234/4885WDR77 1873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.