Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 6/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6513337 | 0.89 | PIK3R1 (0.45) | PIK3R1PIK3CAALDH1A1SMN1; SMN2CHEK1 | |
| SCHEMBL6508464 | 0.86 | CHEK1 (0.53) | PIK3R1PIK3CAALDH1A1SMN1; SMN2CHEK1 | |
| SCHEMBL6507976 | 0.85 | CHEK1 (0.53) | PIK3R1PIK3CAALDH1A1SMN1; SMN2CHEK1 | |
| SCHEMBL6522871 | 0.84 | CHEK1 (0.51) | PIK3R1PIK3CAALDH1A1SMN1; SMN2CHEK1 | |
| SCHEMBL6514168 | 0.82 | PLK1 (0.45) | PIK3R1PIK3CAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL6507120 | 0.82 | MAPT (0.59) | PIK3R1PIK3CAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6514638 | 0.81 | CHEK1 (0.59) | ALDH1A1SMN1; SMN2FABP4FABP5CHEK1 | |
| SCHEMBL6519824 | 0.81 | FAAH (0.44) | PIK3R1PIK3CAALDH1A1 | |
| SCHEMBL6525512 | 0.81 | MAPT (0.51) | PIK3R1PIK3CAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL6522395 | 0.80 | PLK1 (0.45) | PIK3R1PIK3CAALDH1A1SMN1; SMN2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-11-03 | — | — | US | disclosed |
| WO-2005028474-A2 | PYRAZOLOQUINOLINE DERIVATIVES AS CHK-1 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | CHKA, CHKB, CHEK1 | PIK3R1 439/4885PIK3CA 409/4885ALDH1A1 4635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.