Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.51 |
| ▸ | PAK4 | O96013 | 3/20 | 0.51 |
| ▸ | CDK7 | P50613 | 3/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.51 |
| ▸ | CDK1 | P06493 | 2/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.51 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.51 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.51 |
| ▸ | CDC7 | O00311 | 2/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.51 |
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL473432 | 1.00 | KDM4E (0.64) | KDM4EGAAMAPK1MAPK8MAPK9 | |
| SCHEMBL15233041 | 1.00 | KDM4E (0.64) | KDM4EGAAMAPK1MAPK8MAPK9 | |
| Hydrochloric Acid SCHEMBL16041596 | 0.98 | KDM4E (0.62) | KDM4EGAAMAPK1MAPK8MAPK9 | |
| Bromide SCHEMBL21222478 | 0.98 | KDM4E (0.62) | KDM4EGAAMAPK1MAPK8MAPK9 | |
| Bromide SCHEMBL21222476 | 0.98 | KDM4E (0.62) | KDM4EGAAMAPK1MAPK8MAPK9 | |
| SCHEMBL246119 | 0.89 | KDM4E (0.78) | KDM4EGAAMAPK1DRD2DRD3 | |
| SCHEMBL31456684 | 0.88 | KDM4E (0.55) | KDM4EGAAMAPK1MAPK8MAPK9 | |
| Hydrochloric Acid SCHEMBL1936751 | 0.87 | KDM4E (0.75) | KDM4EGAAMAPK1DRD2DRD3 | |
| SCHEMBL29358431 | 0.86 | KDM4E (0.48) | KDM4EGAAMAPK1MAPK8MAPK9 | |
| SCHEMBL12162873 | 0.80 | KDM4E (0.87) | KDM4EGAAMAPK1CCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12404248-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2025-09-02 | — | — | US | disclosed |
| US-20240287004-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2024-08-29 | — | — | US | disclosed |
| US-11945784-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2024-04-02 | — | — | US | disclosed |
| US-20230416271-A1 | HETEROARYLQUINAZOLINE COMPOUNDS AS PROTEIN KINASE INHIBITORS | Chengdu Cynogen Bio-Pharmaceutical Technology Co., Ltd. (CN) | 2023-12-28 | — | — | US | disclosed |
| CN-116601155-A | Heteroaryl quinazoline compounds as protein kinase inhibitors | 成都赛璟生物医药科技有限公司 | 2023-08-15 | — | — | CN | disclosed |
| WO-2022111634-A1 | HETEROARYLQUINAZOLINE COMPOUNDS AS PROTEIN KINASE INHIBITORS | 成都赛璟生物医药科技有限公司 | 2022-06-02 | — | — | WO | disclosed |
| US-20220024878-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2022-01-27 | — | — | US | disclosed |
| WO-2005095339-A1 | DICYANOPYRROLIDINES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | PFIZER PRODUCTS INC. (US) | 2005-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11945784-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | KDM4E 1677/4885GAA 1747/4885MAPK1 914/4885 |
| US-20230416271-A1 | HETEROARYLQUINAZOLINE COMPOUNDS AS PROTEIN KINASE INHIBITORS | CDK9, CDK2, CDK6 | KDM4E 1039/4885GAA 1998/4885MAPK1 226/4885 |
| US-20240287004-A1 | IRE1 SMALL MOLECULE INHIBITORS | XBP1, ERN2, ERN1 | KDM4E 1677/4885GAA 1747/4885MAPK1 914/4885 |
| US-20220024878-A1 | IRE1 SMALL MOLECULE INHIBITORS | XBP1, ERN2, ERN1 | KDM4E 1677/4885GAA 1747/4885MAPK1 914/4885 |
| US-12404248-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | KDM4E 1677/4885GAA 1747/4885MAPK1 914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.