Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.50 |
| ▸ | STS | P08842 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1586006 | 1.00 | GPR119 (0.50) | GPR119STSJAK2JAK1KEAP1 | |
| SCHEMBL25568095 | 0.92 | GPR119 (0.51) | GPR119STSJAK2JAK1KEAP1 | |
| SCHEMBL5477485 | 0.87 | GPR119 (0.52) | GPR119STSJAK2JAK1KEAP1 | |
| SCHEMBL556613 | 0.87 | GPR119 (0.52) | GPR119STSJAK2JAK1KEAP1 | |
| SCHEMBL5477496 | 0.87 | GPR119 (0.52) | GPR119STSJAK2JAK1KEAP1 | |
| SCHEMBL25568094 | 0.86 | GPR119 (0.53) | GPR119STSJAK2JAK1KEAP1 | |
| SCHEMBL556232 | 0.85 | STS (0.53) | GPR119STSJAK2JAK1KEAP1 | |
| SCHEMBL2252656 | 0.85 | STS (0.53) | GPR119STSJAK2JAK1KEAP1 | |
| SCHEMBL29643908 | 0.85 | STS (0.53) | GPR119STSJAK2JAK1KEAP1 | |
| SCHEMBL2253056 | 0.85 | STS (0.53) | GPR119STSJAK2JAK1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119635-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2298775-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2295437-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-16 | — | — | EP | disclosed |