Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of R-Nadolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 9/20 | 1.00 |
| ▸ | ADRB1 known ✓ | P08588 | 6/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | RECQL | P46063 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 5/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.56 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| R-Nadolol SCHEMBL4177 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1TSHRADRA1ALMNA | |
| R-Nadolol SCHEMBL30228708 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1TSHRADRA1ALMNA | |
| Nadolol SCHEMBL1134022 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1TSHRADRA1ALMNA | |
| S-Nadolol SCHEMBL124014 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1TSHRADRA1ALMNA | |
| R-Nadolol SCHEMBL17261862 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1TSHRADRA1ALMNA | |
| R-Nadolol SCHEMBL29687486 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1TSHRADRA1ALMNA | |
| R-Nadolol SCHEMBL1134021 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1TSHRADRA1ALMNA | |
| R-Nadolol SCHEMBL12493069 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1TSHRADRA1ALMNA | |
| R-Nadolol SCHEMBL29809024 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1TSHRADRA1ALMNA | |
| R-Nadolol SCHEMBL28846580 | 0.99 | ADRB2 (0.98) | ADRB2ADRB1TSHRADRA1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005099699-A1 | COMBINATION OF (S)-AMLODIPINE AND A BETA-BLOCKER, AND METHODS FOR REDUCING HYPERTENSION | SEPRACOR INC. (US) | 2005-10-27 | — | — | WO | disclosed |