Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K8 | P41279 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | KRAS | P01116 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | ATR | Q13535 | 4/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.30 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6508762 | 0.87 | KRAS (0.33) | RXRARXRBRXRGKRASABL1 | |
| SCHEMBL6505107 | 0.86 | MAP3K8 (0.42) | MAP3K8RXRARXRBRXRGKRAS | |
| SCHEMBL6508905 | 0.84 | ABL1 (0.32) | RXRARXRBRXRGKRASABL1 | |
| SCHEMBL6506782 | 0.83 | MAP3K8 (0.48) | MAP3K8RXRARXRBRXRGATR | |
| SCHEMBL6503321 | 0.83 | FGFR1 (0.33) | RXRARXRBRXRGABL1ATR | |
| SCHEMBL6510318 | 0.82 | ABL1 (0.36) | RXRARXRBRXRGKRASABL1 | |
| SCHEMBL6512021 | 0.81 | MAP3K8 (0.36) | MAP3K8RXRARXRBRXRGKRAS | |
| SCHEMBL6512277 | 0.81 | MAP3K8 (0.47) | MAP3K8JAK1RXRARXRBRXRG | |
| SCHEMBL6502580 | 0.75 | KRAS (0.33) | MAP3K8RXRARXRBRXRGKRAS | |
| SCHEMBL6504036 | 0.74 | MAP3K8 (0.33) | MAP3K8RXRARXRBRXRGKRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050090529-A1 | 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | PFIZER INC | 2005-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050090529-A1 | 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation | CDK3, CDK4, CDK9 | MAP3K8 143/4885JAK1 109/4885RXRA 2748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.