Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1161927 | 0.87 | TDP1 (0.71) | TDP1ALDH1A1L3MBTL1TSHRGPR35 | |
| SCHEMBL29603881 | 0.87 | TDP1 (0.71) | TDP1ALDH1A1L3MBTL1TSHRGPR35 | |
| SCHEMBL215837 | 0.84 | TDP1 (0.67) | TDP1ALDH1A1L3MBTL1TSHRHTT | |
| SCHEMBL104227 | 0.82 | TDP1 (0.53) | TDP1ALDH1A1L3MBTL1HTTKDM4E | |
| SCHEMBL216473 | 0.78 | ALDH1A1 (0.65) | TDP1ALDH1A1TSHRKDM4EPOLB | |
| SCHEMBL29726496 | 0.78 | ALDH1A1 (0.65) | TDP1ALDH1A1TSHRKDM4EPOLB | |
| 2-Nitroanisole SCHEMBL28204128 | 0.78 | ALDH1A1 (0.79) | TDP1ALDH1A1L3MBTL1HTTADRA2B | |
| SCHEMBL5159608 | 0.77 | TDP1 (0.57) | TDP1ALDH1A1L3MBTL1TSHRHTT | |
| SCHEMBL16590517 | 0.76 | TDP1 (0.47) | TDP1ALDH1A1L3MBTL1TSHRHTT | |
| SCHEMBL17934 | 0.76 | TSHR (0.59) | TDP1ALDH1A1TSHRGPR35POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042495-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-PHENYL-UREA COMPOUNDS AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |