Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.50 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.47 |
| ▸ | CFTR | P13569 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6510323 | 0.76 | HDAC1 (0.52) | IKBKBKMT2AMEN1JAK2EIF2AK2 | |
| SCHEMBL6509110 | 0.76 | IKBKB (0.63) | IKBKBKMT2AMEN1JAK2EIF2AK2 | |
| SCHEMBL6511724 | 0.75 | MAPT (0.51) | IKBKBKMT2AMEN1JAK2EIF2AK2 | |
| SCHEMBL11921318 | 0.75 | IKBKB (0.59) | IKBKBKMT2AMEN1JAK2EIF2AK2 | |
| SCHEMBL6504891 | 0.75 | IKBKB (0.57) | IKBKBKMT2AMEN1JAK2EIF2AK2 | |
| SCHEMBL6530279 | 0.75 | IKBKB (0.48) | IKBKBKMT2AMEN1JAK2EIF2AK2 | |
| SCHEMBL6509621 | 0.74 | SMN1; SMN2 (0.65) | IKBKBKMT2AMEN1NPC1RAB9A | |
| SCHEMBL6503091 | 0.74 | IKBKB (0.50) | IKBKBKMT2AMEN1JAK2EIF2AK2 | |
| SCHEMBL16246484 | 0.74 | NPC1 (0.57) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6512284 | 0.74 | CHEK1 (0.47) | IKBKBKMT2AMEN1JAK2EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |