Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | IKBKB | O14920 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.46 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6510003 | 0.88 | P2RX1 (0.52) | IKBKBMEN1KMT2AJAK2JAK3 | |
| SCHEMBL6509110 | 0.86 | IKBKB (0.63) | CHEK1IKBKBMEN1KMT2AJAK2 | |
| SCHEMBL6530279 | 0.85 | IKBKB (0.48) | CHEK1IKBKBMEN1KMT2AJAK2 | |
| SCHEMBL6506347 | 0.83 | IKBKB (0.61) | CHEK1IKBKBMEN1KMT2AJAK2 | |
| SCHEMBL6511724 | 0.83 | MAPT (0.51) | CHEK1IKBKBMEN1KMT2AJAK2 | |
| SCHEMBL6505096 | 0.82 | IKBKB (0.47) | CHEK1IKBKBMEN1KMT2AJAK2 | |
| SCHEMBL6509621 | 0.82 | SMN1; SMN2 (0.65) | CHEK1IKBKBMEN1KMT2AMAPT | |
| SCHEMBL4087748 | 0.80 | IKBKB (0.73) | CHEK1IKBKBMEN1KMT2AJAK2 | |
| SCHEMBL6503091 | 0.80 | IKBKB (0.50) | CHEK1IKBKBMEN1KMT2AJAK2 | |
| SCHEMBL6507728 | 0.80 | IKBKB (0.50) | IKBKBMEN1KMT2AJAK2EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |