SCHEMBL6509160

SCHEMBL6509160

CC(=O)SCC(=O)c1ccc(-c2ccccn2)s1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.58
HDAC1 Q13547 5/20 0.56
HDAC4 P56524 4/20 0.56
HDAC6 Q9UBN7 4/20 0.56
HDAC3 O15379 3/20 0.56
HDAC7 Q8WUI4 3/20 0.56
HDAC2 Q92769 3/20 0.56
HDAC10 Q969S8 3/20 0.56
HDAC11 Q96DB2 3/20 0.56
HDAC8 Q9BY41 3/20 0.56
HDAC9 Q9UKV0 3/20 0.56
HDAC5 Q9UQL6 3/20 0.56
NPC1 O15118 3/20 0.47
RAB9A P51151 3/20 0.47
MAPT P10636 2/20 0.47
GLA P06280 1/20 0.47
PPARG P37231 1/20 0.47
NR2E3 Q9Y5X4 1/20 0.47
NCOR2 Q9Y618 1/20 0.47
ALDH1A1 P00352 3/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9374034 0.79 KDM4E (0.73) KDM4EHDAC1HDAC4HDAC6HDAC3
SCHEMBL1258592 0.79 KDM4E (0.67) KDM4EHDAC1HDAC4HDAC6HDAC3
SCHEMBL7902381 0.79 KDM4E (0.67) KDM4EHDAC1HDAC4HDAC6HDAC3
SCHEMBL27623934 0.76 KDM4E (0.77) KDM4EHDAC1HDAC4HDAC6HDAC3
SCHEMBL6507559 0.76 HDAC1 (0.69) HDAC1HDAC4HDAC6HDAC3HDAC7
SCHEMBL8381750 0.75 HDAC1 (0.62) KDM4EHDAC1HDAC4HDAC6HDAC3
SCHEMBL29631004 0.75 KDM4E (1.00) KDM4EHDAC1HDAC4HDAC6HDAC3
SCHEMBL373105 0.75 KDM4E (1.00) KDM4EHDAC1HDAC4HDAC6HDAC3
SCHEMBL193466 0.73 KDM4E (0.73) KDM4EHDAC1HDAC4HDAC6HDAC3
SCHEMBL359879 0.73 KDM4E (0.73) KDM4EHDAC1HDAC4HDAC6HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005075466-A1 SUBSTITUTED THIENYL-MERCAPTOKETONES, AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH HISTONE DEACETYLASE ENZYMATIC ACTIVITY ARGENTA DISCOVERY LIMITED (GB) 2005-08-18 WO disclosed
WO-2005075466-A1 SUBSTITUTED THIENYL-MERCAPTOKETONES, AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH HISTONE DEACETYLASE ENZYMATIC ACTIVITY ARGENTA DISCOVERY LIMITED (GB) 2005-08-18 WO disclosed