Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.77 |
| ▸ | HTR2B | P41595 | 3/20 | 0.77 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6511990 | 0.87 | HTR2C (0.80) | HTR2CHTR2BHDAC3HDAC1HDAC2 | |
| SCHEMBL20111165 | 0.87 | HTR2C (1.00) | HTR2CHTR2BHDAC3HDAC1HDAC2 | |
| SCHEMBL6510813 | 0.82 | HTR2C (0.75) | HTR2CHTR2BHDAC3HDAC1HDAC2 | |
| SCHEMBL30604550 | 0.82 | HTR2C (0.81) | HTR2CHTR2BHDAC3HDAC1HDAC2 | |
| SCHEMBL6507511 | 0.82 | HTR2C (0.77) | HTR2CHTR2BHDAC3HDAC1HDAC2 | |
| SCHEMBL6510239 | 0.82 | HTR2C (0.77) | HTR2CHTR2BHDAC3HDAC1HDAC2 | |
| SCHEMBL6508031 | 0.82 | HTR2C (0.77) | HTR2CHTR2BHDAC3HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL30001565 | 0.81 | HTR2C (0.80) | HTR2CHTR2BHDAC3HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL30001608 | 0.81 | HTR2C (0.80) | HTR2CHTR2BHDAC3HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL30001584 | 0.81 | HTR2C (0.76) | HTR2CHTR2BHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040108-A1 | PROLINAMIDE DERIVATIVES AS SODIUM AND/OR CALCIUM CHANNEL BLOCKERS OR SELECTIVE MAO-B INHIBITORS | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2005-05-06 | — | — | WO | claimed |
| WO-2005040108-A1 | PROLINAMIDE DERIVATIVES AS SODIUM AND/OR CALCIUM CHANNEL BLOCKERS OR SELECTIVE MAO-B INHIBITORS | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2005-05-06 | — | — | WO | disclosed |