Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.80 |
| ▸ | HTR2B | P41595 | 3/20 | 0.80 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | CCNK | O75909 | 1/20 | 0.45 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20111165 | 0.89 | HTR2C (1.00) | HTR2CHTR2BHDAC1HDAC3HDAC2 | |
| SCHEMBL13405361 | 0.88 | HTR2C (0.66) | HTR2CHTR2BHDAC1KDM4ECCNK | |
| SCHEMBL30604550 | 0.88 | HTR2C (0.81) | HTR2CHTR2BHDAC1HDAC3HDAC2 | |
| SCHEMBL6509331 | 0.87 | HTR2C (0.77) | HTR2CHTR2BHDAC1HDAC3HDAC2 | |
| SCHEMBL30604551 | 0.87 | HTR2C (0.77) | HTR2CHTR2BHDAC1HDAC3HDAC2 | |
| Hydrochloric Acid SCHEMBL30001565 | 0.87 | HTR2C (0.80) | HTR2CHTR2BHDAC1HDAC3HDAC2 | |
| Hydrochloric Acid SCHEMBL30001608 | 0.87 | HTR2C (0.80) | HTR2CHTR2BHDAC1HDAC3HDAC2 | |
| Hydrochloric Acid SCHEMBL30002187 | 0.86 | HTR2C (0.75) | HTR2CHTR2BHDAC1HDAC3HDAC2 | |
| SCHEMBL6510813 | 0.84 | HTR2C (0.75) | HTR2CHTR2BHDAC1HDAC3HDAC2 | |
| SCHEMBL6510385 | 0.83 | HTR2C (0.73) | HTR2CHTR2BHDAC1HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040108-A1 | PROLINAMIDE DERIVATIVES AS SODIUM AND/OR CALCIUM CHANNEL BLOCKERS OR SELECTIVE MAO-B INHIBITORS | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2005-05-06 | — | — | WO | claimed |
| WO-2005040108-A1 | PROLINAMIDE DERIVATIVES AS SODIUM AND/OR CALCIUM CHANNEL BLOCKERS OR SELECTIVE MAO-B INHIBITORS | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2005-05-06 | — | — | WO | disclosed |