Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | GABRE | P78334 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.34 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7490446 | 0.92 | PLG (0.40) | PLGPLATLMNAGABRPGABRD | |
| SCHEMBL3278388 | 0.92 | PLG (0.40) | PLGPLATLMNAGABRPGABRD | |
| SCHEMBL3997323 | 0.92 | PLG (0.40) | PLGPLATLMNAGABRPGABRD | |
| SCHEMBL14127758 | 0.88 | CHRM2 (0.37) | TSHRCHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL2267594 | 0.88 | CHRM2 (0.37) | TSHRCHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL6509410 | 0.85 | CHRM2 (0.32) | CHRM2CHRM1CHRM4CHRM5CHRM3 | |
| SCHEMBL19431348 | 0.85 | PLG (0.35) | PLGPLATLMNAGABRPGABRD | |
| SCHEMBL19431487 | 0.85 | PLG (0.35) | PLGPLATLMNAGABRPGABRD | |
| SCHEMBL19431480 | 0.85 | PLG (0.35) | PLGPLATLMNAGABRPGABRD | |
| SCHEMBL19431406 | 0.85 | PLG (0.35) | PLGPLATLMNAGABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105814-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2005-11-10 | — | — | WO | disclosed |