Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 5/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2267594 | 0.88 | CHRM2 (0.37) | CHRM2CHRM1CHRM4CHRM5CHRM3 | |
| SCHEMBL14127758 | 0.88 | CHRM2 (0.37) | CHRM2CHRM1CHRM4CHRM5CHRM3 | |
| SCHEMBL6509408 | 0.85 | PLG (0.35) | CHRM2CHRM1CHRM4CHRM5CHRM3 | |
| SCHEMBL12158777 | 0.82 | CHRM2 (0.37) | CHRM2CHRM1CHRM4CHRM5CHRM3 | |
| SCHEMBL14679492 | 0.81 | EPHX2 (0.34) | CHRM2CHRM1CHRM4CHRM3MEN1 | |
| SCHEMBL10939338 | 0.80 | TP53 (0.43) | — | |
| SCHEMBL22054675 | 0.78 | CHRM2 (0.33) | CHRM2CHRM1CHRM4CHRM5CHRM3 | |
| SCHEMBL177205 | 0.78 | — | — | |
| SCHEMBL12476221 | 0.78 | CHRM2 (0.42) | CHRM2CHRM1CHRM4CHRM5CHRM3 | |
| SCHEMBL13804069 | 0.77 | CHRM2 (0.36) | CHRM2CHRM1CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105814-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2005-11-10 | — | — | WO | disclosed |