Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.74 |
| ▸ | S1PR3 | Q99500 | 10/20 | 0.74 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.47 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6505995 | 0.91 | S1PR1 (0.89) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL6529053 | 0.88 | S1PR1 (0.78) | S1PR1S1PR3S1PR4S1PR5 | |
| Hydrochloric Acid SCHEMBL6527438 | 0.87 | S1PR1 (0.76) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL6529498 | 0.85 | S1PR1 (1.00) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL13628896 | 0.79 | S1PR1 (0.69) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL9399589 | 0.78 | RARB (0.55) | S1PR1S1PR3 | |
| SCHEMBL6528028 | 0.78 | S1PR1 (0.61) | S1PR1S1PR3S1PR4S1PR5 | |
| Hydrochloric Acid SCHEMBL6501505 | 0.77 | S1PR1 (0.60) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL6508458 | 0.77 | S1PR1 (0.59) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL15581265 | 0.76 | S1PR1 (0.48) | S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005014525-A2 | BI-ARYL COMPOUND HAVING IMMUNOSUPPRESSIVE ACTIVITY | MITSUBISHI PHARMA CORPORATION (JP) | 2005-02-17 | — | — | WO | disclosed |