Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 7/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 7/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL650823 | 1.00 | CHRNB4 (0.45) | CHRNB4CHRNA3CHRNB2CHRNA4NR1H2 | |
| SCHEMBL650044 | 0.91 | CHRNB2 (0.47) | CHRNB4CHRNA3CHRNB2CHRNA4NR1H2 | |
| SCHEMBL650326 | 0.90 | NR1H2 (0.46) | CHRNB4CHRNA3CHRNB2CHRNA4NR1H2 | |
| SCHEMBL652419 | 0.90 | NR1H2 (0.46) | CHRNB4CHRNA3CHRNB2CHRNA4NR1H2 | |
| SCHEMBL653781 | 0.88 | NR1H2 (0.48) | CHRNB4CHRNA3CHRNB2CHRNA4NR1H2 | |
| SCHEMBL653780 | 0.88 | NR1H2 (0.48) | CHRNB4CHRNA3CHRNB2CHRNA4NR1H2 | |
| SCHEMBL653782 | 0.88 | NR1H2 (0.48) | CHRNB4CHRNA3CHRNB2CHRNA4NR1H2 | |
| SCHEMBL653986 | 0.85 | CHRNB4 (0.48) | CHRNB4CHRNA3CHRNB2CHRNA4NR1H2 | |
| SCHEMBL653985 | 0.85 | CHRNB4 (0.48) | CHRNB4CHRNA3CHRNB2CHRNA4NR1H2 | |
| SCHEMBL2079011 | 0.83 | CHRNB2 (0.46) | CHRNB4CHRNA3CHRNB2CHRNA4NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119635-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2298775-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2295437-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-16 | — | — | EP | disclosed |