Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | PARP1 | P09874 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 5/20 | 0.45 |
| ▸ | CASP7 | P55210 | 2/20 | 0.45 |
| ▸ | CASP2 | P42575 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RGS12 | O14924 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16754925 | 0.81 | GSK3B (0.62) | GSK3BPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL1499914 | 0.76 | GSK3B (0.54) | GSK3BPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL14763938 | 0.76 | GSK3B (0.54) | GSK3BPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL9561195 | 0.76 | GSK3B (0.54) | GSK3BPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL112742 | 0.74 | GSK3B (0.52) | GSK3BPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL10510890 | 0.74 | GSK3B (0.52) | GSK3BPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL1080129 | 0.74 | GSK3B (0.52) | GSK3BPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL11039701 | 0.74 | GSK3B (0.52) | GSK3BPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL5165149 | 0.74 | GSK3B (0.52) | GSK3BPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL10702897 | 0.74 | GSK3B (0.52) | GSK3BPARP1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | claimed |
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |