Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.40 |
| ▸ | TP53 | P04637 | 11/20 | 0.39 |
| ▸ | LMNA | P02545 | 10/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4894596 | 0.86 | MAPT (0.43) | MAPTTP53LMNAKDM4EXBP1 | |
| SCHEMBL4905623 | 0.85 | MAPT (0.47) | MAPTTP53LMNAPPARGPPARA | |
| SCHEMBL4905731 | 0.85 | TP53 (0.44) | MAPTTP53LMNAPPARGPPARA | |
| SCHEMBL4903730 | 0.83 | TP53 (0.45) | MAPTTP53LMNAKDM4EKMT2A | |
| SCHEMBL4903079 | 0.81 | MAPT (0.42) | MAPTTP53LMNAKDM4EPPARG | |
| SCHEMBL4903907 | 0.81 | PPARG (0.45) | MAPTTP53LMNAKDM4EPPARG | |
| SCHEMBL4895897 | 0.80 | TP53 (0.43) | MAPTTP53LMNAKDM4EPPARG | |
| SCHEMBL4906939 | 0.78 | MAPT (0.45) | MAPTTP53LMNAKDM4EXBP1 | |
| SCHEMBL6506709 | 0.77 | MAPT (0.44) | MAPTTP53LMNAMEN1KMT2A | |
| SCHEMBL4906031 | 0.77 | MAPT (0.43) | MAPTTP53LMNAKDM4EXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | MAPT 1786/4885TP53 3421/4885LMNA 319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.