Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.61 |
| ▸ | JAK2 | O60674 | 2/20 | 0.61 |
| ▸ | JAK3 | P52333 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.56 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6530168 | 0.90 | IKBKB (0.62) | IKBKBJAK2JAK3KDRMEN1 | |
| SCHEMBL6509110 | 0.85 | IKBKB (0.63) | IKBKBJAK2JAK3KDRMEN1 | |
| SCHEMBL6530279 | 0.84 | IKBKB (0.48) | IKBKBJAK2JAK3KDRMEN1 | |
| SCHEMBL6507728 | 0.84 | IKBKB (0.50) | IKBKBJAK2JAK3KDRMEN1 | |
| SCHEMBL6508136 | 0.84 | IKBKB (0.60) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6512284 | 0.83 | CHEK1 (0.47) | IKBKBJAK2JAK3KDRMEN1 | |
| SCHEMBL6511724 | 0.82 | MAPT (0.51) | IKBKBJAK2JAK3KDRMEN1 | |
| SCHEMBL6514879 | 0.82 | PARP10 (0.53) | IKBKBKDRMEN1KMT2ACHEK1 | |
| SCHEMBL6505096 | 0.81 | IKBKB (0.47) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6509621 | 0.81 | SMN1; SMN2 (0.65) | IKBKBKDRMEN1KMT2ACHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005051381-A1 | Substituted urea-octatydroindols as antagonists of melanin concentrating hormone receptor 1 (MCH1R) | BIOVITRUM AB (SE) | 2005-06-09 | — | — | WO | claimed |
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |