Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6507043 | 0.81 | HDAC1 (0.50) | TSHRMAOBLMNAKDM4EALDH1A1 | |
| SCHEMBL17682060 | 0.80 | TSHR (0.81) | TSHRKCNH2LTA4HMAOBMEN1 | |
| SCHEMBL11681701 | 0.78 | TSHR (0.68) | TSHRKCNH2LTA4HMAOBMEN1 | |
| SCHEMBL6513490 | 0.76 | TSHR (0.48) | TSHRKCNH2LTA4HMAOBLMNA | |
| SCHEMBL6512171 | 0.76 | SSTR4 (0.41) | TSHRLMNAKDM4E | |
| SCHEMBL5255891 | 0.76 | PDCD1 (0.44) | LTA4HKDM4EALDH1A1 | |
| SCHEMBL22831362 | 0.75 | KCNH2 (0.67) | TSHRKCNH2LTA4HALDH1A1CHRNB2 | |
| SCHEMBL12854780 | 0.74 | APP (0.52) | KCNH2MAOBMEN1KMT2ALMNA | |
| SCHEMBL8430091 | 0.74 | TSHR (0.75) | TSHRKCNH2LTA4HMAOBMEN1 | |
| SCHEMBL11681713 | 0.72 | TSHR (0.77) | TSHRKCNH2LTA4HMAOBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005014588-A1 | SUBSTITUTED THIENYL-HYDROXAMIC ACIDS HAVING HISTONE DEACETYLASE ACTIVITY | ARGENTA DISCOVERY LIMITED (GB) | 2005-02-17 | — | — | WO | disclosed |