Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6509841 | 0.83 | HDAC1 (0.46) | TSHRKDM4EALDH1A1ATMHDAC1 | |
| SCHEMBL6510292 | 0.83 | HDAC1 (0.59) | HDAC1 | |
| SCHEMBL6511431 | 0.81 | HDAC1 (0.46) | TSHRKDM4EALDH1A1ATMLTA4H | |
| SCHEMBL6511346 | 0.80 | HDAC1 (0.38) | TSHRKDM4ELMNAHDAC1 | |
| SCHEMBL6507778 | 0.79 | TSHR (0.40) | TSHRKCNH2MAOBLTA4H | |
| SCHEMBL6513481 | 0.76 | TSHR (0.56) | TSHRKCNH2MAOBKDM4EALDH1A1 | |
| SCHEMBL6509908 | 0.76 | HDAC1 (0.54) | KDM4EHDAC1 | |
| SCHEMBL17682060 | 0.73 | TSHR (0.81) | TSHRKCNH2MAOBKDM4EALDH1A1 | |
| SCHEMBL6509983 | 0.71 | HDAC1 (0.76) | HDAC1 | |
| SCHEMBL11681701 | 0.69 | TSHR (0.68) | TSHRKCNH2MAOBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005014588-A1 | SUBSTITUTED THIENYL-HYDROXAMIC ACIDS HAVING HISTONE DEACETYLASE ACTIVITY | ARGENTA DISCOVERY LIMITED (GB) | 2005-02-17 | — | — | WO | disclosed |