Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GGH | Q92820 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.35 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 7/20 | 0.34 |
| ▸ | LAP3 | P28838 | 2/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | ECE1 | P42892 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL42674 | 0.86 | TP53 (0.38) | GGHMMELAP3ACEECE1 | |
| SCHEMBL42677 | 0.86 | TP53 (0.38) | GGHMMELAP3ACEECE1 | |
| SCHEMBL6845 | 0.84 | TGFBR1 (0.43) | GGHTGFBR1MMELAP3ACE | |
| SCHEMBL6848 | 0.84 | TGFBR1 (0.43) | GGHTGFBR1MMELAP3ACE | |
| SCHEMBL20798046 | 0.84 | TGFBR1 (0.43) | GGHTGFBR1MMELAP3ACE | |
| SCHEMBL13720890 | 0.82 | TGFBR1 (0.42) | GGHTGFBR1MMELAP3ACE | |
| SCHEMBL13720237 | 0.82 | TGFBR1 (0.42) | GGHTGFBR1MMELAP3ACE | |
| SCHEMBL5654860 | 0.82 | TGFBR1 (0.42) | GGHTGFBR1MMELAP3ACE | |
| SCHEMBL13720886 | 0.82 | TGFBR1 (0.42) | GGHTGFBR1MMELAP3ACE | |
| Calcium SCHEMBL5654876 | 0.82 | TGFBR1 (0.42) | GGHTGFBR1MMELAP3ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050221287-A1 | Functional inactivation of cxcr4-mediated responses in growth hormone transgenic mice through socs53 upregulation | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS PHARMACIA SPAIN, S.A. (ES) | 2005-10-06 | — | — | US | disclosed |
| EP-1461614-A2 | FUNCTIONAL INACTIVATION OF CXCR4-MEDIATED RESPONSES IN GROWTH HORMONE TRANSGENIC MICE THROUGH SOCS3 UPREGULATION | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003060521-A2 | FUNCTIONAL INACTIVATION OF CXCR4-MEDIATED RESPONSES IN GROWTH HORMONE TRANSGENIC MICE THROUGH SOCS3 UPREGULATION | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2003-07-24 | — | — | WO | disclosed |