Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | GNRHR | P30968 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649440 | 0.90 | C5AR1 (0.43) | C5AR1ALDH1A1KDM4ESMN1; SMN2GNRHR | |
| SCHEMBL650366 | 0.89 | C5AR1 (0.43) | C5AR1ALDH1A1KDM4ESMN1; SMN2GNRHR | |
| SCHEMBL5135332 | 0.84 | C5AR1 (0.59) | C5AR1ALDH1A1KDM4ESMN1; SMN2GNRHR | |
| SCHEMBL5135904 | 0.83 | C5AR1 (0.56) | C5AR1ALDH1A1KDM4ESMN1; SMN2GNRHR | |
| SCHEMBL648955 | 0.82 | C5AR1 (0.58) | C5AR1ALDH1A1KDM4ESMN1; SMN2GNRHR | |
| SCHEMBL651263 | 0.81 | C5AR1 (0.59) | C5AR1ALDH1A1KDM4ESMN1; SMN2GNRHR | |
| SCHEMBL650896 | 0.80 | C5AR1 (0.52) | C5AR1ALDH1A1KDM4ESMN1; SMN2GNRHR | |
| SCHEMBL649430 | 0.80 | C5AR1 (0.58) | C5AR1ALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL4768447 | 0.79 | C5AR1 (0.64) | C5AR1ALDH1A1KDM4ESMN1; SMN2GNRHR | |
| SCHEMBL5136938 | 0.79 | C5AR1 (0.66) | C5AR1ALDH1A1KDM4ESMN1; SMN2GNRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |