Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 9/20 | 0.74 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | CDC25A | P30304 | 1/20 | 0.45 |
| ▸ | CDC25C | P30307 | 1/20 | 0.45 |
| ▸ | TYMS | P04818 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6508722 | 0.99 | CHEK1 (0.72) | CHEK1KEAP1NFE2L2CDC25ACDC25C | |
| SCHEMBL6508962 | 0.83 | CHEK1 (0.74) | CHEK1PARP1 | |
| SCHEMBL6507585 | 0.83 | CHEK1 (1.00) | CHEK1CDC25ACDC25CTYMSCSF1R | |
| SCHEMBL6046750 | 0.83 | CHEK1 (0.74) | CHEK1TYMSCSF1R | |
| SCHEMBL6509801 | 0.79 | CHEK1 (0.67) | CHEK1CSF1RPARP1 | |
| SCHEMBL4006355 | 0.77 | CHEK1 (1.00) | CHEK1KDM4ESMN1; SMN2 | |
| SCHEMBL4017149 | 0.73 | CHEK1 (1.00) | CHEK1KIF11 | |
| SCHEMBL30577465 | 0.70 | CSF1R (0.48) | CHEK1KEAP1NFE2L2CDC25ACDC25C | |
| SCHEMBL6046741 | 0.70 | CHEK1 (0.55) | CHEK1 | |
| SCHEMBL30577460 | 0.69 | ADORA3 (0.53) | KEAP1NFE2L2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | CHKA, CHKB, CHEK1 | CHEK1 3/4885KEAP1 2533/4885NFE2L2 4557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.