Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6521425 | 0.85 | CHEK1 (0.60) | CHEK1SMN1; SMN2KCNH2ALDH1A1AURKA | |
| SCHEMBL6514638 | 0.83 | CHEK1 (0.59) | CHEK1SMN1; SMN2KCNH2ALDH1A1KDM4E | |
| SCHEMBL6510884 | 0.81 | CHEK1 (0.56) | CHEK1SMN1; SMN2KCNH2ALDH1A1AURKA | |
| SCHEMBL6517612 | 0.80 | CHEK1 (0.58) | CHEK1SMN1; SMN2KCNH2ALDH1A1KDM4E | |
| SCHEMBL6517619 | 0.80 | CHEK1 (0.77) | CHEK1SMN1; SMN2KCNH2ALDH1A1AURKA | |
| SCHEMBL6516725 | 0.78 | CHEK1 (0.59) | CHEK1KCNH2ALDH1A1AURKAKDR | |
| SCHEMBL6508558 | 0.77 | CHEK1 (0.58) | CHEK1SMN1; SMN2KCNH2ALDH1A1AURKA | |
| SCHEMBL6509536 | 0.74 | CHEK1 (0.58) | CHEK1MAPTKCNH2ALDH1A1HTT | |
| SCHEMBL6514629 | 0.74 | CHEK1 (0.49) | CHEK1MAPTKCNH2ALDH1A1HTT | |
| SCHEMBL6525512 | 0.73 | MAPT (0.51) | MAPTSMN1; SMN2TP53ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | CHKA, CHKB, CHEK1 | CHEK1 3/4885MAPT 3744/4885SMN1; SMN2 3724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.