⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15555619 | 1.00 | — | — | |
| SCHEMBL16622749 | 1.00 | — | — | |
| SCHEMBL11872839 | 0.94 | PRCP (0.40) | — | |
| SCHEMBL10610926 | 0.92 | PRCP (0.39) | — | |
| SCHEMBL9579255 | 0.80 | — | — | |
| SCHEMBL17929302 | 0.80 | — | — | |
| SCHEMBL887204 | 0.80 | — | — | |
| SCHEMBL4630954 | 0.80 | — | — | |
| SCHEMBL5969096 | 0.79 | PRCP (0.42) | — | |
| Proline SCHEMBL28915632 | 0.79 | PRCP (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105189481-A | Pyridine cdk9 kinase inhibitors | ABBVIE INC | 2015-12-23 | — | — | CN | disclosed |
| CN-105143221-A | Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders | GALAPAGOS NV | 2015-12-09 | — | — | CN | disclosed |
| CN-100381438-C | New pyrrolidine and thiazolidine compounds, a process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2008-04-16 | — | — | CN | disclosed |
| CN-1721417-A | New pyrrolidine and thiazolidine compounds, a process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2006-01-18 | — | — | CN | disclosed |
| US-20050245563-A1 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-11-03 | — | — | US | disclosed |