Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6517809 | 0.86 | PTGS2 (0.57) | PTGS2PTGS1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL6534957 | 0.78 | PTGS2 (0.71) | PTGS2PTGS1 | |
| SCHEMBL6511244 | 0.77 | PTGS2 (0.50) | PTGS2PTGS1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL6514213 | 0.74 | PTGS2 (0.65) | PTGS2PTGS1 | |
| SCHEMBL6514544 | 0.73 | PTGS2 (0.67) | PTGS2PTGS1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL6520397 | 0.68 | PTGS2 (0.48) | PTGS2PTGS1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL6520481 | 0.67 | PTGS2 (0.61) | PTGS2PTGS1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL1940032 | 0.65 | CYP4F2 (0.44) | PTGS2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6517236 | 0.65 | PTGS2 (0.49) | PTGS2PTGS1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL6515793 | 0.64 | PTGS2 (0.84) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6949536-B2 | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents | PFIZER, INC. (US) | 2005-09-27 | — | — | US | disclosed |
| EP-1086097-B1 | SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER (US) | 2004-05-19 | — | — | EP | disclosed |
| US-6727238-B2 | CYCLOOXYGENASE INHIBITORS | PFIZER INC. | 2004-04-27 | — | — | US | disclosed |
| US-6608095-B2 | Sulfonylbenzene and sulfonamidobenzene compounds which inhibit COX-2; treatment of a medical condition in which prostaglandins are implicated as pathogens | PFIZER INC. | 2003-08-19 | — | — | US | disclosed |
| US-6294558-B1 | ANTIINFLAMMATORY AGENTS AND PROSTAGLANTINS | PFIZER INC. | 2001-09-25 | — | — | US | disclosed |