Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 8/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6281354 | 1.00 | AGTR2 (0.56) | AGTR2NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL15241314 | 1.00 | AGTR2 (0.56) | AGTR2NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL29921 | 1.00 | AGTR2 (0.56) | AGTR2NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL17755338 | 0.91 | AGTR2 (0.47) | AGTR2NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL6941068 | 0.91 | AGTR2 (0.47) | AGTR2NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL20446568 | 0.91 | AGTR2 (0.47) | AGTR2NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL5765292 | 0.91 | AGTR2 (0.47) | AGTR2NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL6901202 | 0.91 | AGTR2 (0.49) | AGTR2NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL116041 | 0.91 | AGTR2 (0.48) | AGTR2POLBBDKRB2 | |
| SCHEMBL20681649 | 0.90 | AGTR2 (0.47) | AGTR2NPC1RAB9ASMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873519-A4 | HIV PROTEASE INHIBITORS | SCRIPPS RESEARCH INST (US) | 2005-04-27 | — | — | EP | disclosed |
| EP-0873519-A1 | HIV PROTEASE INHIBITORS | The Scripps Research Institute (US) | 1998-10-28 | — | — | EP | disclosed |
| WO-1997021100-A1 | HIV PROTEASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1997-06-12 | — | — | WO | disclosed |
| US-4206122-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1980-06-03 | — | — | US | disclosed |