Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 18/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6516013 | 0.86 | CA2 (0.36) | TNFRSF1A | |
| SCHEMBL14524488 | 0.83 | TNFRSF1A (0.47) | TNFRSF1A | |
| SCHEMBL6040640 | 0.83 | TNFRSF1A (0.52) | TNFRSF1A | |
| SCHEMBL6040646 | 0.83 | TNFRSF1A (0.52) | TNFRSF1A | |
| SCHEMBL5559531 | 0.82 | TNFRSF1A (0.45) | TNFRSF1A | |
| SCHEMBL5559533 | 0.82 | TNFRSF1A (0.45) | TNFRSF1A | |
| SCHEMBL6040480 | 0.80 | TNFRSF1A (0.50) | TNFRSF1A | |
| SCHEMBL6040482 | 0.80 | TNFRSF1A (0.50) | TNFRSF1A | |
| SCHEMBL6040605 | 0.79 | TNFRSF1A (0.58) | TNFRSF1A | |
| SCHEMBL6040598 | 0.79 | TNFRSF1A (0.58) | TNFRSF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050049236-A1 | Sulfonamide-substituted chalcone derivatives and their use to treat diseases | CRABTREE ACQUISITION CO, LLC | 2005-03-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049236-A1 | Sulfonamide-substituted chalcone derivatives and their use to treat diseases | STS, HPSE, SULT1E1 | TNFRSF1A 3941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.