Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UPP1 | Q16831 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
| ▸ | DPYD | Q12882 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | GALR3 | O60755 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL584505 | 0.72 | UPP1 (0.59) | UPP1KDM4EALDH1A1MCL1DPYD | |
| SCHEMBL3812728 | 0.68 | UPP1 (0.53) | UPP1KDM4EALDH1A1MCL1DPYD | |
| SCHEMBL31575258 | 0.64 | UPP1 (0.49) | UPP1KDM4EALDH1A1MCL1DPYD | |
| SCHEMBL30903890 | 0.64 | UPP1 (0.49) | UPP1KDM4EALDH1A1MCL1DPYD | |
| SCHEMBL1006471 | 0.63 | CA12 (0.55) | UPP1KDM4EALDH1A1MCL1CRHBP | |
| Hydrochloric Acid SCHEMBL30903877 | 0.62 | CA12 (0.53) | UPP1KDM4EALDH1A1MCL1CRHBP | |
| SCHEMBL3037924 | 0.60 | KDM4E (0.49) | UPP1KDM4EALDH1A1MCL1DPYD | |
| SCHEMBL1008314 | 0.60 | UPP1 (0.44) | UPP1ALDH1A1 | |
| SCHEMBL3048889 | 0.60 | UPP1 (0.53) | UPP1KDM4EALDH1A1MCL1DPYD | |
| SCHEMBL1201107 | 0.60 | KDM4E (0.53) | UPP1KDM4EALDH1A1MCL1DPYD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539769-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS KINASE INHIBITORS | Celltech R & D Limited (GB) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004014920-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS KINASE INHIBITORS | CELLTECH R & D LIMITED (GB) | 2004-02-19 | — | — | WO | disclosed |