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SCHEMBL6517372

SCHEMBL6517372

Cc1c(-c2ccc(OC(F)F)cc2)nc2ccc(-c3cccc(CO)c3)cn12

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ CYP2C9 P11712 1/20 0.41
▸ NR4A2 P43354 1/20 0.41
▸ KCNH2 Q12809 1/20 0.41
▸ SCN5A Q14524 1/20 0.39
▸ CYP11B1 P15538 2/20 0.37
▸ CYP11B2 P19099 2/20 0.37
▸ NR1H4 Q96RI1 4/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ GAA P10253 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ RAB9A P51151 1/20 0.36
▸ SLC2A1 P11166 3/20 0.35
▸ ATM Q13315 1/20 0.35
▸ PPARG P37231 1/20 0.35
▸ PPARA Q07869 1/20 0.35
▸ FYN P06241 2/20 0.35
▸ SLC2A2 P11168 1/20 0.35
▸ PRKCI P41743 1/20 0.34
▸ CHEK1 O14757 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6520038 0.87 NR1H4 (0.47) CYP2C9NR4A2KCNH2CYP11B1CYP11B2
SCHEMBL6523662 0.86 CYP2C9 (0.48) CYP2C9NR4A2KCNH2NR1H4MAPT
SCHEMBL6525530 0.83 CYP2C9 (0.60) CYP2C9NR4A2KCNH2NR1H4ALDH1A1
SCHEMBL6523594 0.78 CYP2C9 (0.48) CYP2C9NR4A2KCNH2NR1H4SLC2A1
SCHEMBL6521013 0.76 CYP2C9 (0.42) CYP2C9NR4A2KCNH2CYP11B1CYP11B2
SCHEMBL3429663 0.76 NR1H4 (0.53) CYP2C9NR4A2KCNH2NR1H4ALDH1A1
SCHEMBL16208185 0.76 CYP2C9 (0.46) CYP2C9NR4A2KCNH2NR1H4SLC2A1
Hydrochloric Acid SCHEMBL6517808 0.76 CYP2C9 (0.41) CYP2C9NR4A2KCNH2CYP11B1CYP11B2
Hydrochloric Acid SCHEMBL6521449 0.75 NR1H4 (0.52) CYP2C9NR4A2KCNH2NR1H4ALDH1A1
SCHEMBL3431513 0.72 GAA (0.46) CYP2C9NR4A2KCNH2GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2262769-B1 POLYSUBSTITUTED 2-ARYL-6-PHENYL-IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC USE THEREOF SANOFI SA (FR) 2014-11-05 — — EP claimed
US-8507520-B2 Polysubstituted 2-aryl-6-phenylimidazo[1,2-A]pyridine derivatives, and preparation and therapeutic use thereof SANOFI (FR) 2013-08-13 — — US claimed
US-20110065745-A1 POLYSUBSTITUTED 2-ARYL-6-PHENYLIMIDAZO[1,2-A]PYRIDINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2011-03-17 — — US claimed
EP-2262769-B1 POLYSUBSTITUTED 2-ARYL-6-PHENYL-IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC USE THEREOF SANOFI SA (FR) 2014-11-05 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110065745-A1 POLYSUBSTITUTED 2-ARYL-6-PHENYLIMIDAZO[1,2-A]PYRIDINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC USE THEREOF JAK2, ABL1, REN CYP2C9 212/4885NR4A2 1394/4885KCNH2 1641/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.