Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.47 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | WNT3A | P56704 | 1/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.45 |
| ▸ | F3 | P13726 | 1/20 | 0.45 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.45 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4962574 | 0.85 | HDAC1 (0.57) | HDAC1HDAC8PLOD2ALDH1A1PLOD3 | |
| SCHEMBL552456 | 0.81 | HDAC1 (0.63) | HDAC1HDAC8PLOD2ALDH1A1PLOD3 | |
| SCHEMBL11624584 | 0.81 | HDAC1 (0.63) | HDAC1HDAC8PLOD2ALDH1A1PLOD3 | |
| SCHEMBL31030252 | 0.81 | HDAC1 (0.63) | HDAC1HDAC8PLOD2ALDH1A1PLOD3 | |
| SCHEMBL7075878 | 0.80 | PLOD2 (0.69) | HDAC1HDAC8PLOD2ALDH1A1PLOD3 | |
| SCHEMBL552357 | 0.80 | HDAC1 (0.66) | HDAC1HDAC8PLOD2ALDH1A1L3MBTL1 | |
| SCHEMBL2945748 | 0.79 | HDAC1 (0.65) | HDAC1HDAC8PLOD2ALDH1A1PLOD3 | |
| SCHEMBL30096366 | 0.79 | HDAC1 (0.65) | HDAC1HDAC8PLOD2ALDH1A1PLOD3 | |
| SCHEMBL551914 | 0.78 | HDAC1 (0.68) | HDAC1HDAC8PLOD2ALDH1A1L3MBTL1 | |
| SCHEMBL552045 | 0.78 | HDAC1 (0.68) | HDAC1HDAC8PLOD2ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050130116-A1 | Stable expression of polymorphous forms of human cytochrome p450 2d6 | DOHMER JOHANNES (DE) | 2005-06-16 | — | — | US | disclosed |
| EP-1220943-B1 | Cellular test system for investgation of metabolic activity of active forms of cytochrome P450 2D6 | DOEHMER JOHANNES (DE) | 2004-07-14 | — | — | EP | disclosed |