Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | IDE | P14735 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6518300 | 0.85 | AURKA (0.45) | AURKAKDRAURKBCHEK1 | |
| SCHEMBL6509375 | 0.85 | AURKA (0.45) | AURKAKDRAURKBCHEK1KCNH2 | |
| SCHEMBL6512223 | 0.85 | CHEK1 (0.51) | AURKAKDRAURKBCHEK1KDM4E | |
| SCHEMBL6514590 | 0.83 | AURKA (0.46) | AURKAKDRAURKBCHEK1KCNH2 | |
| SCHEMBL6519572 | 0.83 | CHEK1 (0.47) | AURKAKDRAURKBCHEK1KCNH2 | |
| SCHEMBL6519862 | 0.82 | AURKA (0.44) | AURKAKDRAURKBCHEK1KCNH2 | |
| SCHEMBL6520896 | 0.82 | REN (0.42) | AURKAKDRAURKBCHEK1 | |
| SCHEMBL6518416 | 0.81 | CHEK1 (0.47) | AURKAKDRAURKBCHEK1KCNH2 | |
| SCHEMBL6510076 | 0.80 | AURKA (0.57) | AURKAKDRAURKBCHEK1KCNH2 | |
| SCHEMBL6508848 | 0.79 | AURKA (0.54) | AURKAKDRAURKBCHEK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-11-03 | — | — | US | disclosed |
| WO-2005028474-A2 | PYRAZOLOQUINOLINE DERIVATIVES AS CHK-1 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | CHKA, CHKB, CHEK1 | AURKA 78/4885KDR 1094/4885AURKB 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.