Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | MARS1 | P56192 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6520655 | 1.00 | NPC1 (0.42) | NPC1RAB9AKDM4ECRHBPCRHR2 | |
| SCHEMBL1481480 | 0.93 | KDM4E (0.44) | NPC1RAB9AKDM4ECRHBPCRHR2 | |
| SCHEMBL1481483 | 0.93 | KDM4E (0.44) | NPC1RAB9AKDM4ECRHBPCRHR2 | |
| SCHEMBL1480792 | 0.91 | DRD2 (0.44) | NPC1RAB9AHDAC6P2RX3PIK3CG | |
| SCHEMBL1480789 | 0.91 | DRD2 (0.44) | NPC1RAB9AHDAC6P2RX3PIK3CG | |
| SCHEMBL1480229 | 0.89 | KDM4E (0.40) | NPC1RAB9AKDM4ECRHBPCRHR2 | |
| SCHEMBL1480227 | 0.89 | KDM4E (0.40) | NPC1RAB9AKDM4ECRHBPCRHR2 | |
| SCHEMBL1481171 | 0.88 | SMN1; SMN2 (0.43) | NPC1RAB9AKDM4ECRHBPCRHR2 | |
| SCHEMBL1481174 | 0.88 | SMN1; SMN2 (0.43) | NPC1RAB9AKDM4ECRHBPCRHR2 | |
| SCHEMBL1482031 | 0.88 | KDM4E (0.43) | NPC1RAB9AKDM4ECRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050187277-A1 | Substituted azole derivatives, compositions, and methods of use | TRANSTECH PHARMA, INC. | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050187277-A1 | Substituted azole derivatives, compositions, and methods of use | PTPRO, PTPN5, PTPRE | NPC1 3228/4885RAB9A 3396/4885KDM4E 733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.