Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.36 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL648302 | 0.97 | AGTR1 (0.38) | AGTR1LPAR1LPAR5CMKLR1DRD2 | |
| SCHEMBL649495 | 0.96 | TLR8 (0.36) | AGTR1LPAR1LPAR5CMKLR1DRD2 | |
| SCHEMBL652771 | 0.95 | TLR8 (0.36) | AGTR1LPAR1LPAR5CMKLR1DRD2 | |
| SCHEMBL648072 | 0.94 | AGTR1 (0.39) | AGTR1DRD2TBXA2RLTB4R2 | |
| SCHEMBL650292 | 0.93 | HDAC1 (0.35) | AGTR1LPAR1LPAR5CMKLR1DRD2 | |
| SCHEMBL651303 | 0.93 | MC4R (0.37) | AGTR1LPAR1LPAR5CMKLR1DRD2 | |
| SCHEMBL651300 | 0.91 | AGTR1 (0.35) | AGTR1LPAR1LPAR5CMKLR1DRD2 | |
| SCHEMBL648274 | 0.91 | AGTR1 (0.35) | AGTR1LPAR1LPAR5CMKLR1DRD2 | |
| SCHEMBL650986 | 0.91 | AGTR1 (0.35) | AGTR1CMKLR1DRD2TBXA2RTLR8 | |
| SCHEMBL648516 | 0.91 | LTB4R2 (0.40) | AGTR1AGTR2LTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |