Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TET2 | Q6N021 | 3/20 | 0.43 |
| ▸ | KDM4A | O75164 | 2/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.43 |
| ▸ | TET3 | O43151 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 10/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.41 |
| ▸ | GRM8 | O00222 | 1/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22194081 | 1.00 | TET2 (0.43) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL20298459 | 1.00 | TET2 (0.43) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL22194080 | 1.00 | TET2 (0.43) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL381680 | 1.00 | TET2 (0.43) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL4995749 | 1.00 | TET2 (0.43) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL382032 | 1.00 | TET2 (0.43) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL168206 | 0.98 | TET2 (0.44) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL130992 | 0.98 | TET2 (0.44) | TET2KDM4AKDM4CKDM2ATET3 | |
| SCHEMBL168205 | 0.98 | TET2 (0.44) | TET2KDM4AKDM4CKDM2ATET3 | |
| Ammonia Solution, Strong SCHEMBL30578431 | 0.96 | TET2 (0.43) | TET2KDM4AKDM4CKDM2ATET3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119684-B2 | Thiophene derivatives for up-regulating HLA-DM activity | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2012-02-21 | — | — | US | disclosed |
| US-20100183658-A1 | Novel Compounds for Enhancing MHC Class II Therapies | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2010-07-22 | — | — | US | disclosed |
| US-20100143404-A1 | Thiophene derivatives for up-regulating HLA-DM activity | THE BRIGHAM & WOMEN'S HOSPITAL, INC. | 2010-06-10 | — | — | US | disclosed |
| EP-2134176-A1 | COMPOUNDS AND METHODS FOR ENHANCING MHC CLASS II THERAPIES | The Brigham and Women's Hospital, Inc. (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008121836-A1 | COMPOUNDS AND METHODS FOR ENHANCING MHC CLASS II THERAPIES | BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2008-10-09 | — | — | WO | disclosed |
| WO-2005066152-A1 | THIOPHENE DERIVATIVES FOR UP-REGULATING HLA-DM ACTIVITY | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2005-07-21 | — | — | WO | disclosed |
| EP-0030461-B1 | DETERGENT COMPOSITION | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1983-05-04 | — | — | EP | disclosed |
| US-4349447-A | Phosphate-free detergent composition | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1982-09-14 | — | — | US | disclosed |
| EP-0030461-A1 | Detergent composition | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1981-06-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100183658-A1 | Novel Compounds for Enhancing MHC Class II Therapies | HLA-DRB1, CD74, MICA | TET2 1022/4885KDM4A 967/4885KDM4C 776/4885 |
| US-20100143404-A1 | Thiophene derivatives for up-regulating HLA-DM activity | HLA-DRB1, CD74, HLA-C | TET2 2778/4885KDM4A 1751/4885KDM4C 1602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.