Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 6/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3572550 | 0.86 | NR1H2 (0.45) | SPRNR1H2USP30GPR119 | |
| SCHEMBL3572552 | 0.86 | NR1H2 (0.45) | SPRNR1H2USP30GPR119 | |
| SCHEMBL652371 | 0.75 | PARP1 (0.49) | SPRGPR119JAK2JAK1 | |
| SCHEMBL7689008 | 0.75 | PARP1 (0.49) | SPRGPR119JAK2JAK1 | |
| SCHEMBL18711487 | 0.75 | NR1H2 (0.45) | SPRNR1H2USP30 | |
| SCHEMBL3578707 | 0.74 | GPR119 (0.46) | SPRUSP30GPR119JAK2JAK1 | |
| SCHEMBL3578711 | 0.74 | GPR119 (0.46) | SPRUSP30GPR119JAK2JAK1 | |
| SCHEMBL3578710 | 0.74 | GPR119 (0.46) | SPRUSP30GPR119JAK2JAK1 | |
| SCHEMBL18701818 | 0.74 | NR1H2 (0.44) | SPRNR1H2USP30 | |
| SCHEMBL1672859 | 0.74 | HCRTR2 (0.52) | SPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119635-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2298775-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2295437-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-16 | — | — | EP | disclosed |