Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | DRD4 | P21917 | 2/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2149225 | 0.78 | CHRM1 (0.43) | CHRM1CHRM2CHRM4CHRM5DRD2 | |
| SCHEMBL2149657 | 0.72 | CHRM1 (0.43) | CHRM1CHRM2CHRM4CHRM5DRD2 | |
| SCHEMBL6444666 | 0.67 | CHRM1 (0.39) | CHRM1CHRM2CHRM4CHRM5DRD2 | |
| SCHEMBL7069097 | 0.65 | ADRA1D (0.39) | CHRM1CHRM2CHRM4CHRM5DRD2 | |
| SCHEMBL7131386 | 0.65 | CHRM1 (0.42) | CHRM1CHRM2CHRM4CHRM5DRD2 | |
| SCHEMBL6460781 | 0.65 | CHRM1 (0.39) | CHRM1CHRM2CHRM4CHRM5DRD2 | |
| SCHEMBL2149826 | 0.63 | CHRM1 (0.45) | CHRM1CHRM2CHRM4CHRM5DRD2 | |
| SCHEMBL7135550 | 0.63 | CHRM1 (0.47) | CHRM1CHRM2CHRM4CHRM5DRD2 | |
| SCHEMBL6451141 | 0.63 | CHRM1 (0.47) | CHRM1CHRM2CHRM4CHRM5DRD2 | |
| SCHEMBL6523687 | 0.62 | ADRA1D (0.41) | ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432420-A4 | BENZIMIDAZOLIDINONE DERIVATIVES AS MUSCARINIC AGENTS | ACADIA PHARM INC (US) | 2005-11-09 | — | — | EP | disclosed |
| EP-1432420-A2 | BENZIMIDAZOLIDINONE DERIVATIVES AS MUSCARINIC AGENTS | Acadia Pharmaceuticals Inc. (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028650-A2 | BENZIMIDAZOLIDINONE DERIVATIVES AS MUSCARINIC AGENTS | ACADIA PHARMACEUTICALS, INC. (US) | 2003-04-10 | — | — | WO | disclosed |