Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.33 |
| ▸ | C5AR1 | P21730 | 13/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MYC | P01106 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6522128 | 0.87 | C5AR1 (0.31) | C5AR1 | |
| SCHEMBL6523381 | 0.77 | C5AR1 (0.41) | C5AR1 | |
| SCHEMBL3816531 | 0.74 | GAA (0.40) | MEN1KMT2AKDM4EPOLB | |
| SCHEMBL1327940 | 0.73 | SMN1; SMN2 (0.48) | MEN1KMT2AKDM4EPOLB | |
| SCHEMBL1327060 | 0.71 | C5AR1 (0.31) | C5AR1ELANE | |
| SCHEMBL6523352 | 0.69 | C5AR1 (0.38) | C5AR1 | |
| SCHEMBL1327995 | 0.68 | C5AR1 (0.40) | C5AR1 | |
| SCHEMBL1327363 | 0.68 | C5AR1 (0.40) | C5AR1 | |
| SCHEMBL1327189 | 0.68 | FFAR1 (0.39) | C5AR1 | |
| SCHEMBL1328263 | 0.67 | C5AR1 (0.41) | C5AR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565452-A2 | 3-SUBSTITUTED-6-ARYL PYRIDINES AS LIGANDS OF C5A RECEPTORS | NEUROGEN CORPORATION (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004043925-A2 | 3-SUBSTITUTED-6-ARYL PYRIDINED AS LIGANDS OF C5A RECEPTORS | NEUROGEN CORPORATION (US) | 2004-05-27 | — | — | WO | disclosed |